Identification of new developmentally regulated genes involved in Streptomyces coelicolor sporulation.

ABSTRACT:

Background

The sporulation of aerial hyphae of Streptomyces coelicolor is a complex developmental process. Only a limited number of the genes involved in this intriguing morphological differentiation programme are known, including some key regulatory genes. The aim of this study was to expand our knowledge of the gene repertoire involved in S. coelicolor sporulation.

Results

We report a DNA microarray-based investigation of developmentally controlled gene expression in S. coelicolor. By comparing global transcription patterns of the wild-type parent and two mutants lacking key regulators of aerial hyphal sporulation, we found a total of 114 genes that had significantly different expression in at least one of the two mutants compared to the wild-type during sporulation. A whi

SUBMITTER: Salerno P 

PROVIDER: S-EPMC3878966 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature