Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers.

ABSTRACT:

Context

Alzheimer's disease (AD) is usually only diagnosed many years after pathology begins. Earlier detection would allow emerging interventions to have a greater chance to preserve healthy brain function. A rare form of Alzheimer's disease, caused by autosomal-dominant mutations, affects carriers with 100% certainty and at a younger age specific to their mutation. Studying families with these mutations allows a unique investigation of the temporal sequence of biomarker changes in Alzheimer's disease.

Objective

To determine whether the pupil flash response (PFR), previously reported to be altered in sporadic Alzheimer's disease, is different in pre-symptomatic mutation carriers.

Design

Researchers blinded to participant mutation status collected pupil response data

SUBMITTER: Frost SM 

PROVIDER: S-EPMC3879087 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature