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Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy.

ABSTRACT: A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC3879136 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy.

Cheng Yu Y   Morshed Ramin R   Cheng Shih-Hsun SH   Tobias Alex A   Auffinger Brenda B   Wainwright Derek A DA   Zhang Lingjiao L   Yunis Catherine C   Han Yu Y   Chen Chin-Tu CT   Lo Leu-Wei LW   Aboody Karen S KS   Ahmed Atique U AU   Lesniak Maciej S MS  

Small (Weinheim an der Bergstrasse, Germany) 20130721 24

A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma c  ...[more]

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