CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior.

ABSTRACT:

Background

Overexpression of CD98hc (SLC3A2) occurs in a variety of cancers and is suspected to contribute to tumor growth. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin β subunit cytoplasmic domains via its heavy chain, CD98hc. CD98hc regulates adhesion-induced intracellular signal transduction via integrins, thereby, affecting cell proliferation and clonal expansion. Disruption of CD98hc led to embryonic lethality in mice (E 3.5 and E 9.5) and CD98hc -/- embryonic stem cell transplantation failed to form teratomas, while CD98hc over-expression in somatic cells resulted in anchorage-independent growth. However, it is unclear whether interference with CD98hc expression tumor cell behavior.

Methods

Renal cell cancer cell lines have b

SUBMITTER: Poettler M 

PROVIDER: S-EPMC3879186 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature