Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response.

ABSTRACT:

Background

Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host responses in individuals infected with the chikungunya virus are not well understood at the molecular level. We carried out proteomic profiling of serum samples from chikungunya patients in order to identify molecules associated with the host response to infection by this virus.

Results

Proteomic profiling of serum obtained from the infected individuals resulted in identification of 569 proteins. Of these, 63 proteins were found to be differentially expressed (≥ 2-fold) in patient as compared to control sera. These differentially expressed proteins were i

SUBMITTER: Puttamallesh VN 

PROVIDER: S-EPMC3879382 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature