Modularity and evolutionary constraints in a baculovirus gene regulatory network.

ABSTRACT:

Background

The structure of regulatory networks remains an open question in our understanding of complex biological systems. Interactions during complete viral life cycles present unique opportunities to understand how host-parasite network take shape and behave. The Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) is a large double-stranded DNA virus, whose genome may encode for 152 open reading frames (ORFs). Here we present the analysis of the ordered cascade of the AgMNPV gene expression.

Results

We observed an earlier onset of the expression than previously reported for other baculoviruses, especially for genes involved in DNA replication. Most ORFs were expressed at higher levels in a more permissive host cell line. Genes with more than one copy in the geno

SUBMITTER: Oliveira JV 

PROVIDER: S-EPMC3879405 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature