Differential modulation of innate immunity in vitro by probiotic strains of Lactobacillus gasseri.

ABSTRACT:

Background

Probiotics species appear to differentially regulate the intestinal immune response. Moreover, we have shown that different immune-modulatory abilities can be found among probiotic strains belonging to the same species. In this study, we further addressed this issue while studying L. gasseri, a species that induces relevant immune activities in human patients.

Results

We determined the ability of two strains of L. gasseri, OLL2809 and L13-Ia, to alter cell surface antigen expression, cytokine production and nuclear erythroid 2-related factor 2 (Nrf2)-mediated cytoprotection in murine bone marrow-derived dendritic cells (DCs) and MODE-K cells, which represent an enterocyte model. Differential effects of L. gasseri strains were observed on the expression of surface

SUBMITTER: Luongo D 

PROVIDER: S-EPMC3879436 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature