Serum sclerostin levels vary with season.

ABSTRACT:

Context

To establish the clinical utility of serum sclerostin levels, it is important to know whether there is seasonal variation in the measurements.

Objective

This study was done to determine whether serum sclerostin levels vary by season in healthy older men and women.

Methods

Serum sclerostin levels were measured in archived serum of 314 healthy men and women aged 65 years and older and examined for seasonal variation. Several factors known to vary by season and previously reported to be associated with serum sclerostin levels, including serum osteocalcin, physical activity, and serum PTH levels, were also measured in these subjects. Sex did not modify the association of season with sclerostin, so the men and women were analyzed together.

Results

Serum scle

SUBMITTER: Dawson-Hughes B 

PROVIDER: S-EPMC3879665 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature