Insulin resistance indices are inversely associated with vitamin D binding protein concentrations.

ABSTRACT:

Context

We hypothesized that, similar to the coordinated homeostatic regulation of most hormones, the concentration of free and bioavailable 25-hydroxyvitamin D [25(OH)D] will be tightly controlled by total 25(OH)D and vitamin D binding protein (VDBP) and that the VDBP concentrations will be associated with insulin resistance status.

Objective

Our primary objective was to investigate associations between total, free, and bioavailable 25(OH)D and VDBP. We also evaluated the relationships of VDBP with insulin resistance indices.

Study design

The study design was cross-sectional in the setting of a university children's hospital. The relative concentration of bioavailable 25(OH)D to total 25(OH)D [bioavailable 25(OH)D/total 25(OH)D was expressed as a percentage [percenta

SUBMITTER: Ashraf AP 

PROVIDER: S-EPMC3879668 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature