TNF-α haplotype association with polycystic ovary syndrome - a South Indian study.

ABSTRACT:

Background

Tumor Necrosis Factor Alpha (TNF-α), is a proinflammatory cytokine in the pathogenesis of Polycystic Ovary Syndrome (PCOS). In order to investigate the role of rs1800629 and rs1799964 polymorphisms in relation to anthropometric measures, family history of complex diseases, diet and clinical features, we performed a case control study in PCOS women from South India.

Methods

A total of 589 samples comprising of 283 patients and 306 controls were enrolled in the present study. Patients were selected based on Rotterdam criteria and ultrasound scanned normal women were selected as controls. Following extraction of DNA, genotyping for rs1800629 and rs1799964 was performed by polymerase chain reaction using tetra primers and PCR-RFLP respectively.

Results

The dist

SUBMITTER: Deepika ML 

PROVIDER: S-EPMC3879940 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature