Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis.

ABSTRACT: Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a recent global expansion of a virulent clone. However, the availability of a single genome for this species has so far prevented testing this hypothesis at genomic scales. We present here the sequence of three additional strains from clinical and environmental samples. Our analyses reveal unexpected patterns of genomic variation, shared among distant strains, that argue against the clonal expansion hypothesis. All strains carry independent expansions involving an arsenite transporter homolog, pointin

SUBMITTER: Pryszcz LP 

PROVIDER: S-EPMC3879973 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature