Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis.

ABSTRACT:

Background

Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey matter volume in people at ultra-high risk (UHR) of psychosis; however, little is known about cortical thickness in this group. The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis.

Method

We examined magnetic resonance imaging data collected at four different scanning sites. The UHR subjects were followed up for at least 2 years. Subsequent to scanning, 50 UHR subjects developed psychosis and 117 did not. Cortical thickness was examined in regions previously identified as sites of neuroanatomical altera

SUBMITTER: Tognin S 

PROVIDER: S-EPMC3880065 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature