Reprogramming of lysosomal gene expression by interleukin-4 and Stat6.

ABSTRACT:

Background

Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood. The goal of this study was to illuminate the physiological contexts in which lysosomal genes are coordinately regulated and to identify transcription factors involved in this control.

Results

As transcription factors and their target genes are often co-regulated, we performed meta-analyses of array-based expression data to identify regulators whose mRNA profiles are highly correlated with those of a core set of lysosomal genes. Among the ~50 transcription factors that rank highest by this measure, 65% are involved in differentiation or development, and 22% have been implicated in interferon si

SUBMITTER: Brignull LM 

PROVIDER: S-EPMC3880092 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature