Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.
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ABSTRACT:
SUBMITTER: Wojtovich AP
PROVIDER: S-EPMC3880126 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
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Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.
Wojtovich Andrew P AP Smith C Owen CO Haynes Cole M CM Nehrke Keith W KW Brookes Paul S PS
Biochimica et biophysica acta 20130102 5
In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K(+) (mKATP) channel. This review will address the involvement of complex II in each of these areas, with a focus on how complex II regulates or may be involve ...[more]
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