Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial.

ABSTRACT:

Background

Recurrent aphthous stomatitis (RAS) is a painful condition of unknown etiology, affecting more than 2.5 billion people worldwide. Vitamin deficiencies have been implicated as a possible cause.

Methods

The authors conducted a single-center, randomized, parallel-arm, double-masked, placebo-controlled study to examine the effect of daily multivitamin supplementation on the number and duration of RAS episodes. The authors randomly assigned 160 adults who had a validated history of at least three episodes of idiopathic minor RAS within the previous 12 months to one of two groups: the first group (n = 83) received a once-daily multivitamin containing 100 percent of the U.S. reference daily intake (RDI) of essential vitamins, and the second group (n = 77) received once-d

SUBMITTER: Lalla RV 

PROVIDER: S-EPMC3880249 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature