Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

ABSTRACT: The Dominantly Inherited Alzheimer's Network Trials Unit (DIAN-TU) was formed to direct the design and management of interventional therapeutic trials of international DIAN and autosomal dominant Alzheimer's disease (ADAD) participants. The goal of the DIAN-TU is to implement safe trials that have the highest likelihood of success while advancing scientific understanding of these diseases and clinical effects of proposed therapies. The DIAN-TU has launched a trial design that leverages the existing infrastructure of the ongoing DIAN observational study, takes advantage of a variety of drug targets, incorporates the latest results of biomarker and cognitive data collected during the observational study, and implements biomarkers measuring Alzheimer's disease (AD) biological processes to imp

SUBMITTER: Mills SM 

PROVIDER: S-EPMC3880800 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature