Sequencing of the IL6 gene in a case-control study of cerebral palsy in children.

ABSTRACT:

Background

Cerebral palsy (CP) is a group of nonprogressive disorders of movement and posture caused by abnormal development of, or damage to, motor control centers of the brain. A single nucleotide polymorphism (SNP), rs1800795, in the promoter region of the interleukin-6 (IL6) gene has been implicated in the pathogenesis of CP by mediating IL-6 protein levels in amniotic fluid and cord plasma and within brain lesions. This SNP has been associated with other neurological, vascular, and malignant processes as well, often as part of a haplotype block.

Methods

To refine the regional genetic association with CP, we sequenced (Sanger) the IL6 gene and part of the promoter region in 250 infants with CP and 305 controls.

Results

We identified a haplotype of 7 SNPs that incl

SUBMITTER: Khankhanian P 

PROVIDER: S-EPMC3881497 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature