Association of MDM2 SNP309, age of onset, and gender in cutaneous melanoma.

ABSTRACT:

Purpose

In certain cancers, MDM2 SNP309 has been associated with early tumor onset in women. In melanoma, incidence rates are higher in women than in men among individuals less than 40 years of age, but among those older than 50 years of age, melanoma is more frequent in men than in women. To investigate this difference, we examined the association among MDM2 SNP309, age at diagnosis, and gender among melanoma patients.

Experimental design

Prospectively enrolled melanoma patients (N = 227) were evaluated for MDM2 SNP309 and the related polymorphism, p53 Arg72Pro. DNA was isolated from patient blood samples, and genotypes were analyzed by PCR-restriction fragment length polymorphism. Associations among MDM2 SNP309, p53 Arg72Pro, age at diagnosis, and clinicopathologic feature

SUBMITTER: Firoz EF 

PROVIDER: S-EPMC3881546 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature