Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study.

ABSTRACT:

Background

Previous studies in occupational exposure and lung function have focused only on the main effect of occupational exposure or genetics on lung function. Some disease-susceptible genes may be missed due to their low marginal effects, despite potential involvement in the disease process through interactions with the environment. Through comprehensive genome-wide gene-environment interaction studies, we can uncover these susceptibility genes. Our objective in this study was to explore gene by occupational exposure interaction effects on lung function using both the individual SNPs approach and the genetic network approach.

Methods

The study population comprised the Offspring Cohort and the Third Generation from the Framingham Heart Study. We used forced expiratory vol

SUBMITTER: Liao SY 

PROVIDER: S-EPMC3882096 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature