Distinct roles for N-Cadherin linked c-Src and fyn kinases in lens development.

ABSTRACT:

Background

Src family tyrosine kinases (SFKs) are often coincidently expressed but few studies have dissected their individual functions in the same cell during development. Using the classical embryonic lens as our model, we investigated SFK signaling in the regulation of both differentiation initiation and morphogenesis, and the distinct functions of c-Src and Fyn in these processes.

Results

Blocking SFK activity with the highly specific inhibitor PP1 induced initiation of the lens differentiation program but blocked lens fiber cell elongation and organization into mini lens-like structures called lentoids. These dichotomous roles for SFK signaling were discovered to reflect distinct functions of c-Src and Fyn and their differentiation-state-specific recruitment to and act

SUBMITTER: Leonard M 

PROVIDER: S-EPMC3882121 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature