The effects of a problem solving-based intervention on depressive symptoms and HIV medication adherence are independent.

ABSTRACT: Depression and depressive symptoms predict poor adherence to medical therapy, but the association is complex, nonspecific, and difficult to interpret. Understanding this association may help to identify the mechanism explaining the results of interventions that improve both medical therapy adherence and depressive symptoms as well as determine the importance of targeting depression in adherence interventions. We previously demonstrated that Managed Problem Solving (MAPS) focused on HIV medication adherence improved adherence and viral load in patients initiating a new antiretroviral regimen. Here, we assessed whether MAPS improved depressive symptoms and in turn, whether changes in depressive symptoms mediated changes in adherence and treatment outcomes. We compared MAPS to usual care with

SUBMITTER: Gross R 

PROVIDER: S-EPMC3882274 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature