Reduced ADAMTS13 activity is associated with an ADAMTS13 SNP, fever and microparticles in a malaria-like model.

ABSTRACT:

Background

Severe falciparum malaria (SM) remains a major cause of death in tropical countries. The reduced activity of ADAMTS13, increasing levels of ultra-large von Willebrand factor (ULVWF) in SM patients, are assumed as factors that intensify disease severity. However, the reason why ADAMTS13 activity is reduced in SM remains unclear.

Objectives

To investigate whether rs4962153, febrile temperature, and microparticles, contribute to reduced ADAMTS13 activity.

Methods

Genotypic association of rs4962153 with ADAMTS13 antigen and activity was examined in 362 healthy Thai participants. The collagen binding assay was used to study the effects of febrile temperature and microparticles on ADAMTS13 activity.

Results

ADAMTS13 antigen and activity were decreased in p

SUBMITTER: Kraisin S 

PROVIDER: S-EPMC3882324 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature