Overexpression of kallikrein gene 10 is a biomarker for predicting poor prognosis in gastric cancer.

ABSTRACT:

Aim

To analyze the expression of kallikrein gene 10 (KLK10) in gastric cancer and to determine whether KLK10 has independent prognostic value in gastric cancer.

Methods

We studied KLK10 expression in 80 histologically confirmed gastric cancer samples using real-time quantitative reverse transcription-PCR and hK10 expression using immunohistochemistry. Correlations with clinicopathological variables (lymph node metastasis, depth of invasion and histology) and with outcomes (disease-free survival and overall survival) during a median follow-up period of 31 mo were assessed. Gastric cancer tissues were then classified as KLK10 positive or negative.

Results

KLK10 was found to be highly expressed in 57/80 (70%) of gastric cancer samples, while its expression was very low i

SUBMITTER: Jiao X 

PROVIDER: S-EPMC3882418 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature