Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: a meta-analysis.

ABSTRACT:

Aim

To clarify the current understanding of the association between interleukin-10 (IL-10) polymorphisms and the risk of irritable bowel syndrome (IBS).

Methods

We searched for studies in any language recorded in PubMed, Embase and Cochrane library before August 2013. The associations under allele contrast model, codominant model, dominant model, and recessive model were analyzed. The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios (OR) with 95% confidence interval (CI). Fixed effects model was used to pool the result if the test of heterogeneity was not significant, otherwise the random-effect model was selected.

Results

Eight case-control studies analyzing three single-nucleotide polymorphisms rs1800870 (-1082 A

SUBMITTER: Qin SY 

PROVIDER: S-EPMC3882424 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature