Divergent transcription is associated with promoters of transcriptional regulators.

ABSTRACT:

Background

Divergent transcription is a wide-spread phenomenon in mammals. For instance, short bidirectional transcripts are a hallmark of active promoters, while longer transcripts can be detected antisense from active genes in conditions where the RNA degradation machinery is inhibited. Moreover, many described long non-coding RNAs (lncRNAs) are transcribed antisense from coding gene promoters. However, the general significance of divergent lncRNA/mRNA gene pair transcription is still poorly understood. Here, we used strand-specific RNA-seq with high sequencing depth to thoroughly identify antisense transcripts from coding gene promoters in primary mouse tissues.

Results

We found that a substantial fraction of coding-gene promoters sustain divergent transcription of long n

SUBMITTER: Lepoivre C 

PROVIDER: S-EPMC3882496 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature