B cells modulate mucosal associated invariant T cell immune responses.

ABSTRACT: A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings show the presence in uninfected individuals of mucosal associated invariant T (MAIT) cells that mount broad spectrum immune responses against a variety of microorganisms including Mycobacterium tuberculosis and enteric bacteria such as Escherichia coli and Salmonella. Therefore, we investigated whether MAIT immune responses to intestinal bacteria might account for the background responses observed before immunization. Here we measured MAIT immune responses to commensal and enteric pathogenic bacteria in healthy individuals with no history of

SUBMITTER: Salerno-Goncalves R 

PROVIDER: S-EPMC3882667 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature