XB130 promotes proliferation and invasion of gastric cancer cells.

ABSTRACT:

Background

XB130 has been reported to be expressed by various types of cells such as thyroid cancer and esophageal cancer cells, and it promotes the proliferation and invasion of thyroid cancer cells. Our previous study demonstrated that XB130 is also expressed in gastric cancer (GC), and that its expression is associated with the prognosis, but the role of XB130 in GC has not been well characterized.

Methods

In this study, we investigated the influence of XB130 on gastric tumorigenesis and metastasis in vivo and in vitro using the MTT assay, clonogenic assay, BrdU incorporation assay, 3D culture, immunohistochemistry and immunofluorescence. Western blot analysis was also performed to identify the potential mechanisms involved.

Results

The proliferation, migration, an

SUBMITTER: Shi M 

PROVIDER: S-EPMC3882781 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature