Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment.

ABSTRACT:

Background aims

Advantages associated with the use of cord blood (CB) transplantation include the availability of cryopreserved units, ethnic diversity and lower incidence of graft-versus-host disease compared with bone marrow or mobilized peripheral blood. However, poor engraftment remains a major obstacle. We and others have found that ex vivo fucosylation can enhance engraftment in murine models, and now ex vivo treatment of CB with fucosyltransferase (FT) VI before transplantation is under clinical evaluation (NCT01471067). However, FTVII appears to be more relevant to hematopoietic cells and may alter acceptor substrate diversity. The present study compared the ability of FTVI and FTVII to improve the rapidity, magnitude, multi-lineage and multi-tissue engraftment of human CB

SUBMITTER: Robinson SN 

PROVIDER: S-EPMC3883688 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature