Gene-by-age effects on BMI from birth to adulthood: the Fels Longitudinal Study.

ABSTRACT:

Objectives

Genome wide association studies have shown 32 loci to influence BMI in European-American adults but replication in other studies is inconsistent and may be attributed to gene-by-age effects. The aims of this study were to determine if the influence of the summed risk score of these 32 loci (GRS) on BMI differed across age from birth to 40 years, and to determine if additive genetic effects other than those in the GRS differed by age.

Methods

Serial measures of BMI were calculated at 0, 1, 3, 6, 9, 12, 18, and 28 months, and 4, 7, 11, 15, 19, 23, 30, and 40 years for 1,176 (605 females, 571 males) European-American participants in the Fels Longitudinal Study. SOLAR was used for genetic analyses.

Results

GRS was significant (P < 0.05) at ages: 6, 9 months, 4-

SUBMITTER: Choh AC 

PROVIDER: S-EPMC3883986 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature