A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation.

ABSTRACT:

Objective

To carry out a systematic review of the literature addressing cognitive functions in first-episode psychosis (FEP), divided into domains. Although this is not a full "cognitive-genetics-in-schizophrenia review," we will also include putative ideas of mechanism(s) behind these impairments, focusing on how early stress, and genetic vulnerability may moderate cognitive function in psychosis.

Method

Relevant studies were identified via computer literature searches for research published up to and including January 2013, only case-control studies were included for the neurocognitive meta-analysis.

Results

Patients with FEP present global cognitive impairment compared to healthy controls. The largest effect size was observed for verbal memory (Cohen's d effect siz

SUBMITTER: Aas M 

PROVIDER: S-EPMC3884147 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature