Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case-control study with clinical correlates.

ABSTRACT:

Introduction

Sarcoidosis is an incurable, chronic granulomatous disease primarily involving the lungs and lymph nodes of unknown aetiology, treated with non-specific anti-inflammatory/immunosuppressive drugs. Persistently symptomatic patients worsen with a disabling, potentially fatal clinical course. To determine a possible infectious cause, we correlated in a case-control study the clinical information with the presence of bacterial DNA in sarcoidosis mediastinal lymph nodes compared with control lymph nodes resected during cancer surgery.

Methods

We retrospectively studied formalin-fixed, paraffin-embedded, mediastinal lymph nodes from 30 patients with sarcoidosis and 30 control patients with lung cancer. Nucleic acids were extracted from nodes, evaluated by ribosomal RNA

SUBMITTER: Robinson LA 

PROVIDER: S-EPMC3884606 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature