Efficacy and safety of duloxetine 60 mg once daily in major depressive disorder: a review with expert commentary.

ABSTRACT:

Objective

Major depressive disorder (MDD) is a significant public health concern and challenges health care providers to intervene with appropriate treatment. This article provides an overview of efficacy and safety information for duloxetine 60 mg/day in the treatment of MDD, including its effect on painful physical symptoms (PPS).

Design

A literature search was conducted for articles and pooled analyses reporting information regarding the use of duloxetine 60 mg/day in placebo-controlled trials.

Setting

Placebo-controlled, active-comparator, short- and long-term studies were reviewed.

Participants

Adult (≥18 years) patients with MDD.

Measurements

Effect sizes for continuous outcome (change from baseline to endpoint) and categorical outcome (response an

SUBMITTER: Ball SG 

PROVIDER: S-EPMC3884746 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature