Reducing agents decrease the oxidative burst and improve clinical outcomes in COPD patients: a randomised controlled trial on the effects of sulphurous thermal water inhalation.

ABSTRACT:

Background

Inhalation of thermal water with antioxidant properties is empirically used for COPD.

Aims

To evaluate the effects of sulphurous thermal water (reducing agents) on airway oxidant stress and clinical outcomes in COPD.

Methods

Forty moderate-to-severe COPD patients were randomly assigned to receive 12-day inhalation with sulphurous thermal water or isotonic saline. Patients were assessed for superoxide anion (O2 (-)) production in the exhaled breath condensate and clinical outcomes at recruitment, the day after the conclusion of the 12-day inhalation treatment, and one month after the end of the inhalation treatment.

Results

Inhalation of reducing agents resulted in a significant reduction of O2 (-) production in exhaled breath condensate of COPD patie

SUBMITTER: Contoli M 

PROVIDER: S-EPMC3884964 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature