Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: an update.

ABSTRACT:

Background

The inflammatory hypothesis of schizophrenia is not new, but recently it has regained interest because more data suggest a role of the immune system in the pathogenesis of schizophrenia. If increased inflammation of the brain contributes to the symptoms of schizophrenia, reduction of the inflammatory status could improve the clinical picture. Lately, several trials have been conducted investigating the potential of anti-inflammatory agents to improve symptoms of schizophrenia. This study provides an update regarding the efficacy of anti-inflammatory agents on schizophrenic symptoms in clinical studies performed so far.

Methods

An electronic search was performed using PubMed, Embase, the National Institutes of Health web site http://www.clinicaltrials.gov, Cochrane

SUBMITTER: Sommer IE 

PROVIDER: S-EPMC3885306 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature