Dynamics of regulatory networks in gastrin-treated adenocarcinoma cells.

ABSTRACT: Understanding gene transcription regulatory networks is critical to deciphering the molecular mechanisms of different cellular states. Most studies focus on static transcriptional networks. In the current study, we used the gastrin-regulated system as a model to understand the dynamics of transcriptional networks composed of transcription factors (TFs) and target genes (TGs). The hormone gastrin activates and stimulates signaling pathways leading to various cellular states through transcriptional programs. Dysregulation of gastrin can result in cancerous tumors, for example. However, the regulatory networks involving gastrin are highly complex, and the roles of most of the components of these networks are unknown. We used time series microarray data of AR42J adenocarcinoma cells treated wi

SUBMITTER: Doni Jayavelu N 

PROVIDER: S-EPMC3885390 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature