6 Minute walk test in Duchenne MD patients with different mutations: 12 month changes.

ABSTRACT:

Objective

In the last few years some of the therapeutical approaches for Duchenne muscular dystrophy (DMD) are specifically targeting distinct groups of mutations, such as deletions eligible for skipping of individual exons. The aim of this observational study was to establish whether patients with distinct groups of mutations have different profiles of changes on the 6 minute walk test (6MWT) over a 12 month period.

Methods

The 6MWT was performed in 191 ambulant DMD boys at baseline and 12 months later. The results were analysed using a test for heterogeneity in order to establish possible differences among different types of mutations (deletions, duplications, point mutations) and among subgroups of deletions eligible to skip individual exons.

Results

At baseline th

SUBMITTER: Pane M 

PROVIDER: S-EPMC3885414 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature