Post-stroke mortality, stroke severity, and preadmission antipsychotic medicine use--a population-based cohort study.

ABSTRACT:

Background and purpose

It has been suggested that antipsychotic medication may be neuroprotective and may reduce post-stroke mortality, but studies are few and ambiguous. We aimed to investigate the post-stroke effects of preadmission antipsychotic use.

Methods

We conducted a nationwide, population-based cohort study of 81,143 persons admitted with stroke in Denmark from 2003-2010. Using Danish health care databases, we extracted data on preadmission use of antipsychotics and confounding factors. We examined the association between current, former, and never use of antipsychotics and stroke severity, length of hospital stay, and 30-day post-stroke mortality using logistic regression analysis, survival analysis, and propensity score matching.

Results

Current users of a

SUBMITTER: Prior A 

PROVIDER: S-EPMC3885530 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature