Prognostic significance of MET amplification and expression in gastric cancer: a systematic review with meta-analysis.

ABSTRACT:

Background and aims

MET, the hepatocyte growth factor receptor, is a receptor tyrosine kinase overexpressed and activated in a subset of gastric cancer. Several studies investigated the relationship between MET amplification and expression with the clinical outcome in patients with gastric cancer, but yielded conflicting results. We performed a systematic review and meta-analysis to determine the influence of MET amplification and expression on prognosis in gastric cancer.

Methods

MEDLINE and EMBASE were searched for studies that explored the association between MET amplification and expression with survival in patients with gastric cancer up to 1 April, 2013. Data of individual hazard ratios (HRs) and 95% confidence intervals (CIs) for meta-analyses were extracted from the

SUBMITTER: Peng Z 

PROVIDER: S-EPMC3885582 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature