QuantWorm: a comprehensive software package for Caenorhabditis elegans phenotypic assays.

ABSTRACT: Phenotypic assays are crucial in genetics; however, traditional methods that rely on human observation are unsuitable for quantitative, large-scale experiments. Furthermore, there is an increasing need for comprehensive analyses of multiple phenotypes to provide multidimensional information. Here we developed an automated, high-throughput computer imaging system for quantifying multiple Caenorhabditis elegans phenotypes. Our imaging system is composed of a microscope equipped with a digital camera and a motorized stage connected to a computer running the QuantWorm software package. Currently, the software package contains one data acquisition module and four image analysis programs: WormLifespan, WormLocomotion, WormLength, and WormEgg. The data acquisition module collects images and video

SUBMITTER: Jung SK 

PROVIDER: S-EPMC3885606 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature