Low GILT Expression is Associated with Poor Patient Survival in Diffuse Large B-Cell Lymphoma.

ABSTRACT: The major histocompatibility complex (MHC) class II-restricted antigen processing pathway presents antigenic peptides acquired in the endocytic route for the activation of CD4(+) T cells. Multiple cancers express MHC class II, which may influence the anti-tumor immune response and patient outcome. Low MHC class II expression is associated with poor survival in diffuse large B-cell lymphoma (DLBCL), the most common form of aggressive non-Hodgkin lymphoma. Therefore, we investigated whether gamma-interferon-inducible lysosomal thiol reductase (GILT), an upstream component of the MHC class II-restricted antigen processing pathway that is not regulated by the transcription factor class II transactivator, may be important in DLBCL biology. GILT reduces protein disulfide bonds in the endocytic c

SUBMITTER: Phipps-Yonas H 

PROVIDER: S-EPMC3885809 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature