The effect of donor age on penetrating keratoplasty for endothelial disease: graft survival after 10 years in the Cornea Donor Study.

ABSTRACT:

Objective

To determine whether the 10-year success rate of penetrating keratoplasty for corneal endothelial disorders is associated with donor age.

Design

Multicenter, prospective, double-masked clinical trial.

Participants

A total of 1090 participants undergoing penetrating keratoplasty at 80 sites for Fuchs' dystrophy (62%), pseudophakic/aphakic corneal edema (34%), or another corneal endothelial disorder (4%) and followed for up to 12 years.

Methods

Forty-three eye banks provided corneas from donors aged 12 to 75 years, using a randomized approach to assign donor corneas to study participants without respect to recipient factors. Surgery and postoperative care were performed according to the surgeons' usual routines.

Main outcome measures

Graft failur

SUBMITTER: Writing Committee for the Cornea Donor Study Research Group 

PROVIDER: S-EPMC3885822 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature