The κ-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial.

ABSTRACT:

Objectives

We examined the pharmacogenetic association between a variant in the κ-opioid receptor (OPRK1) gene and the response to treatment with a cocaine vaccine tested in a recent clinical trial (October 2003 to April 2005). This gene has a protective allele for opioid addiction that may act by the inhibiting dopamine activation associated with reinforcement.

Methods

Sixty-nine DNA samples were obtained from 114 cocaine-dependent and opioid-dependent patients who were enrolled in a 16-week phase IIb randomized double-blind placebo-controlled trial and received five vaccinations over the first 12 weeks. We genotyped 66 of these patients for the rs6473797 variant of the OPRK1 gene and compared vaccine patients with placebo patients in terms of cocaine-free urines over time.

SUBMITTER: Nielsen DA 

PROVIDER: S-EPMC3885873 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature