MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation.

ABSTRACT:

Background

Lung transplantation remains the only viable treatment option for the majority of patients with advanced lung diseases. However, 5-year post-transplant survival rates remain low primarily secondary to chronic rejection. Novel insights from global gene expression profiles may provide molecular phenotypes and therapeutic targets to improve outcomes after lung transplantation.

Methods

Whole-genome gene expression profiling was performed in a cohort of patients that underwent lung transplantation as well as healthy controls using the Affymetrix Human Exon 1.0ST Array. To explore the potential roles of microRNAs (miRNAs) in regulating lung transplantation-associated gene dysregulation, miRNA expression levels were also profiled in the same samples using the Exiqon miRC

SUBMITTER: Zhang W 

PROVIDER: S-EPMC3886917 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature