Two-step source tracing strategy of Yersinia pestis and its historical epidemiology in a specific region.

ABSTRACT: Source tracing of pathogens is critical for the control and prevention of infectious diseases. Genome sequencing by high throughput technologies is currently feasible and popular, leading to the burst of deciphered bacterial genome sequences. Utilizing the flooding genomic data for source tracing of pathogens in outbreaks is promising, and challenging as well. Here, we employed Yersinia pestis genomes from a plague outbreak at Xinghai county of China in 2009 as an example, to develop a simple two-step strategy for rapid source tracing of the outbreak. The first step was to define the phylogenetic position of the outbreak strains in a whole species tree, and the next step was to provide a detailed relationship across the outbreak strains and their suspected relatives. Through this strategy,

SUBMITTER: Yan Y 

PROVIDER: S-EPMC3887043 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature