APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.

ABSTRACT:

Background

Proton magnetic resonance spectroscopy ((1)H-MRS) studies on healthy aging have reported inconsistent findings and have not systematically taken into account the possible modulatory effect of APOE genotype. We aimed to quantify brain metabolite changes in healthy subjects in relation to age and the presence of the APOE E4 genetic risk factor for Alzheimer's disease. Additionally, we examined these measures in relation to cognition.

Methods

We studied a cohort of 112 normal adults between 50 and 86 years old who were genotyped for APOE genetic polymorphism. Measurements of (1)H-MRS metabolites were obtained in the posterior cingulate and precuneus region. Measures of general cognitive functioning, memory, executive function, semantic fluency, and speed of processin

SUBMITTER: Gomar JJ 

PROVIDER: S-EPMC3887136 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature