Parental diabetes and birthweight in 236 030 individuals in the UK biobank study.

ABSTRACT:

Background

The UK Biobank study provides a unique opportunity to study the causes and consequences of disease. We aimed to use the UK Biobank data to study the well-established, but poorly understood, association between low birthweight and type 2 diabetes.

Methods

We used logistic regression to calculate the odds ratio for participants' risk of type 2 diabetes given a one standard deviation increase in birthweight. To test for an association between parental diabetes and birthweight, we performed linear regression of self-reported parental diabetes status against birthweight. We performed path and mediation analyses to test the hypothesis that birthweight partly mediates the association between parental diabetes and participant type 2 diabetes status.

Results

Of the

SUBMITTER: Tyrrell JS 

PROVIDER: S-EPMC3887570 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature