Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers.

ABSTRACT:

Background

Major impediments to development of vaccines and drugs for Plasmodium vivax malaria are the inability to culture this species and the extreme difficulty in undertaking clinical research by experimental infection.

Methods

A parasite bank was collected from a 49-year-old woman with P. vivax infection, characterized, and used in an experimental infection study.

Results

The donor made a full recovery from malaria after collection of a parasite bank, which tested negative for agents screened for in blood donations. DNA sequence analysis of the isolate indicated that it was clonal. Two subjects inoculated with the isolate became polymerase chain reaction positive on days 8 and 9, with onset of symptoms and positive blood smears on day 14, when they were treated w

SUBMITTER: McCarthy JS 

PROVIDER: S-EPMC3888148 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature