ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA.

ABSTRACT:

Objective

To test the hypothesis that higher levels of red blood cell (RBC) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have a protective association with domain-specific cognitive function in women aged 65 years and older.

Methods

A total of 2,157 women with normal cognition enrolled in a clinical trial of postmenopausal hormone therapy were followed with annual cognitive testing for a median of 5.9 years. In this retrospective cohort study, we assessed the relationship between prerandomization RBC DHA + EPA levels and a) cognitive measures at baseline, and b) cognitive change over time. Endpoints were composite cognitive function and performance in 7 cognitive domains: fine motor speed, verbal memory, visual memory, spatial ability, verbal knowledge, verbal

SUBMITTER: Ammann EM 

PROVIDER: S-EPMC3888166 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature