A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects.

ABSTRACT:

Objective

In this multicenter cohort study, we sought to identify prognostic and associative metabolic indicators for HIV-associated neurocognitive disorders (HAND).

Methods

A quantitative lipidomic analysis was conducted on 524 longitudinal CSF samples collected from 7 different performance sites across the mainland United States, Hawaii, and Puerto Rico. Subjects included HIV-infected individuals with longitudinal clinical and cognitive testing data and cognitively normal HIV-negative healthy controls.

Results

At baseline, HIV+ subjects could be differentiated from HIV- controls by reductions in a single ceramide species and increases in multiple forms of cholesterol. Perturbations in cholesterol metabolism and ceramide were influenced by combined antiretroviral the

SUBMITTER: Bandaru VV 

PROVIDER: S-EPMC3888167 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature