Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients.

ABSTRACT:

Objective

To report the clinical features of 20 newly diagnosed patients with GABAB receptor (GABABR) antibodies and determine the frequency of associated tumors and concurrent neuronal autoantibodies.

Methods

Clinical data were retrospectively obtained and evaluated. Serum and CSF samples were examined for additional antibodies using methods previously reported.

Results

Seventeen patients presented with seizures, memory loss, and confusion, compatible with limbic encephalitis (LE), one patient presented with ataxia, one patient presented with status epilepticus, and one patient presented with opsoclonus-myoclonus syndrome (OMS). Nineteen (95%) patients eventually developed LE during the course of the disease. Small-cell lung cancer (SCLC) was identified in 10 (50%) p

SUBMITTER: Hoftberger R 

PROVIDER: S-EPMC3888170 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature